C. Stelt, A. J. Zwart Voorspuij, W. Nauta
2006
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Antonie van Leeuwenhoek
Abstract
SummarySeventy-five compounds, derivatives of 4-nitro-benzoic acid and of 4-amino-benzoic acid, were investigated for their tuberculostatic activity. The majority showed practically no activity in the concentrations studied. A number of 4-nitro-benzoic acid esters of branched alcohols, which proved to be active on the synthetic medium, showed a considerably lower activity on the protein-containing Beeuwkes medium.The synthesis of the esters mentioned, and that of n-hexylamino-benzoic acid, 4-acetylamino-3-amino-benzoic acid, and 5,5′-dinitro-2,2′-dicarboxy-diphenyl is described. The melting point of 4-thio-ureido-benzoic acid was higher than 330°C. in our investigation, and was not at 255°C. as mentioned in the literature.