Liao Zhi-hao, Cheng Guang-hui
2011
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Journal
China Pharmacy
Abstract
OBJECTIVE:To study the compatible stability of Cefotiam hydrochloride for injection and Ambroxol hydrochloride injection in 0.9% Sodium chloride injection at room temperature. METHODS:At various time points within 8 h, the contents of cefotiam and ambroxol hydrochloride were determined by RP-HPLC-DAD. The outward appearance of the solution was observed, and the pH value was determined. RESULTS:Within 8 h at (20±1)℃, obvious changes were demonstrated in the outward appearance, pH value and the contents of the solution. CONCLUSION:Cefotiam hydrochloride cannot be combined with Ambroxol hydrochloride injection in 0.9% Sodium chloride injection at (20±1)℃.