N. I. Traven', T. S. Safonova
May 1, 1981
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0
Influential Citations
2
Citations
Journal
Chemistry of Heterocyclic Compounds
Abstract
The reaction of 2-mercapto-3-ureido- and 2-mercapto-3-aminopyridines with β-halo derivatives of carbonyl compounds (ketones, acids, and aldehydes) and with acrylonitrile proceeds not only via the mercapto group but also via the amino group, as a result of which S-β-keto (carboxy, cyano) alkyl, N,S-bis(β-ketoalkyl), and N,S-diacyl derivatives of pyridine are formed. The action of acids, alkalis, and dehydrating agents on 2-S-β-keto (carboxy, cyano) ethyl-3-aminoureidopyridines was studied. A method for the preparation of derivatives of a new heterocyclic system, viz., 6-oxopyrido [2,3-b] [1,5] thiazepine, by the reaction of 2-mercapto-3-aminopyridines with β-bromopropionic acid and subsequent treatment of 2-(β-car-boxyethyl) thio-8-aminopyridines with dicyclohexylcarbodiimide was developed.