Lisa A. Hasvold, Le Wang, Magdalena Przytulinska
Apr 1, 2008
Citations
0
Influential Citations
12
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
The synthesis and structure-activity relationships (SAR) of Chk1 inhibitors based on a 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one core are described. Specifically, an exploration of the 7 and 8 positions on this previously disclosed core afforded compounds with improved enzymatic and cellular potency.