A. Kremzer, Yu. V. Strokin, N. A. Klyuev
Aug 1, 1981
Citations
0
Influential Citations
0
Citations
Journal
Chemistry of Heterocyclic Compounds
Abstract
Depending on the nature and amount of the base used, as well as the reaction time, the following compounds are formed in the reaction of 8-aminothiophyl-lines with glycerol epichlorohydrin in anhydrous propanol; 7-(2-hydroxy-3-chloro-1-propyl)-8-arylaminotheophylline, 1,3-bis(8-arylamino-7-theophyllinyl)-2-hydroxypropane, 7-(2,3-epoxy-1-propy1)-8-alkyl(aryl) aminothiophyllines or 9-alkyl(aryl)-7-hydroxy-1,3-dimethyl-6,7,8,9-tetrahydropyrimido [2,1-f]purine-2,4-(1H,3H)diones. The structures of the compounds were confirmed by alternative synthesis and by data from the IR spectra. The mass spectrum of one of the compounds is presented.