Y. Dacheng
2009
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Journal
Journal of Southwest University
Abstract
The carboxyl and amino groups of L-tyrosine were protected with methyl esterification for the carboxyl group and with tert-butyloxy carbonylation for the amino group,and then the hydroxyl group was alkylated with n-butyl bromide and methyl-bromoacetate alternatively.Thus two new L-tyrosine derivatives(Ia and Ib) were obtained with an overall yield 74.5% and 75.6%,respectively.The established synthesis technology of L-tyrosine derivatives has advantages over other known ways for its facile operation and low cost.Therefore it has a promising prospect of commercial application.The chemical structures of the compounds were confirmed by MS,IR,1H NMR and 13C NMR.