I. Setnikar, V. De Fina
May 1, 1970
Citations
0
Influential Citations
2
Citations
Quality indicators
Journal
Toxicology and applied pharmacology
Abstract
Abstract The acute toxicity of moquizone (a choleretic drug) was investigated in mice, rats, and rabbits. Oral toxic doses exerted depressant effects, whereas parenteral toxic doses exerted stimulant effects on the central nervous system. In mice the LD50 values were 1155 mg/kg oral, 237 iv; in rats, 2135 mg/kg oral, 146 iv; in rabbits, 1650 mg/kg oral and 180 iv. The daily administration of 31.25 mg/kg to rats for 6 months did not provoke toxic signs. The daily dose of 62.5 mg/kg retarded growth slightly. The daily dose of 250 mg/kg for 3 months provoked toxic signs, particularly in the liver and in the blood. These toxic signs were more severe with 500 mg/kg daily (3 months) or 1000 mg/kg daily (1 month). In dogs 160 mg/kg daily for 6 months did not cause chronic toxic signs, but, occasionally, acute overstimulation of the central nervous system. Daily doses of 320 mg/kg resulted in deaths, due to convulsions following the dosage, in 2 2 dogs within 1 month.