C. Helt, Wensheng Wang, P. Keng
Jan 28, 2005
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Influential Citations
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Quality indicators
Journal
Cell Cycle
Abstract
The toroidal Rad9-Rad1-Hus1 checkpoint complex (9-1-1) is structurally similarto the proliferating cell nuclear antigen (PCNA), which serves as a sliding clamp platformfor DNA replication and repair. 9-1-1 has been characterized as a sensor of DNAdamage that functions in concert with the checkpoint control proteins ATM and ATR.However, recent data suggest that the 9-1-1 complex and its individual Rad9 componentserve different and multiple functions in cells by sensing DNA damage, stimulatingapoptosis, and regulating gene transcription. Recently it was reported that 9-1-1 interactswith and/or stimulates components of the base excision repair (BER) pathway includingthe S. pombe MutY homolog (MYH), human polymerase ? (Pol ?), and flapendonuclease 1 (FEN1). Furthermore, preliminary results indicate a stimulation of DNAligase I. In this review, the likely direct participation of 9-1-1 in DNA repair isdiscussed.