A. L. Noce, F. Demicheli, I. Filatori
1995
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Abstract
Iomeprol is a new nonionic monomeric contrast medium for intravascular use. This study assesses its neurological safety. First, microdialysis experiments have shown that small amounts of iomeprol can be detected in the cerebrospinal fluid (CSF) following the intravascular administration of the compound without any apparent damage to the blood-brain barrier. Secondly, no significant changes in the normal parameters of visual-evoked potentials or in the basal levels of several neurotransmitters have been observed following direct administration of iomeprol to the rat’s nervous system. It is concluded that iomeprol is highly neurotolerable, possibly because of its low molecular toxicity.