Yali Song, Fan Wu, Chaochao Zhang
Jan 15, 2015
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Influential Citations
26
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Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
2-(Indole-3-yl)-thiochroman-4-ones were synthesized via ionic liquid and tested for in vitro antifungal activity. The contribution of ionic liquid to Michael addition reaction is significant. Structures of all compounds are elucidated by (1)H NMR, (13)C NMR and HRMS. Most of these compounds showed better antifungal activity than fluconazole. The results suggest that 2-(indole-3-yl)-thiochroman-4-ones would be efficient antifungal agents.