D. V. Sowbhagyam, D. Koteswararao, Dr. K Prameela
Sep 30, 2023
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Journal
International Journal for Research in Applied Science and Engineering Technology
Abstract
Abstract: A series of 5-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)thiazolidine-2,4-dione derivatives were synthesised by the Claisen-Schmidt condensation of 1,3-diphenyl-1H-pyrazole-4-carbaldehyde with thiazolidine-2,4-dione using Ionic liquid under both conventional heating method and microwave irradiation method. All the synthesised derivatives were screened for their anticancer activity against three different human cell lines as cervix (SiHa), brest (MDA-MB-231) and pancreatic carcinoma (PANC-1) using the Sulforhodamine B assay method.