R. Bases, R. Lekhraj
2018
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0
Influential Citations
1
Citations
Journal
Journal of Bioanalysis & Biomedicine
Abstract
Lucanthone, a thiaxanthenone, once widely used to treat schistosomiasis, induced 3.6 fold increases in immune globulin G (IgG) relative to immune globulin M (IgM) in CRL-1647 Burkitt’s lymphoma cells [1]. This increase persisted for many generations and was accompanied by 7 fold increases in cellular activation induced cytidine deaminase (AID) [1]. AID is a key factor in Ig class switching from IgM to IgG.