M. V. Kuznetsova, S. S. Ryasenskii, I. P. Gorelov
Nov 1, 2003
Citations
0
Influential Citations
3
Citations
Journal
Pharmaceutical Chemistry Journal
Abstract
Dimedrol (benzhydrol -dimethylaminoethyl ester hydrochloride, Dim HCl) is a widely used antihistamine possessing local anesthetic and spasmolytic properties [1]. This drug is available in the form of 0.02, 0.03, and 0.05 g tablets and 1% solution for injections (in ampules). The analytical monitoring of dimedrol is usually performed by titrimetric techniques [2], which are insufficiently sensitive and selective and involve a rather tedious procedure that hinders batch analyses. An interesting alternative is offered by direct ionometry using ion-selective electrodes (ISEs). Membrane ISEs sensitive to DimH+ ions were described in [3, 4]. The function of ion – electron transducer is performed by an internal reference electrode so that the ion-selective membrane is permanently in contact with the aqueous solution. As a result, the electroactive substance is gradually washed out of the membrane, which significantly reduces the working life of such electrodes. Moreover, the presence of an internal solution reduces the working pH range and increases the electrode response time. These disadvantages can be eliminated by using an ion – electron transducer based on an electrically conducting polymer [5 – 7]. The aim of this study was to develop a solid ISE reversible with respect to DimH ions, with an ion – electron transducer based on the electrically conducting polymer poly( -naphthylamine) (PNA).