Wen-Bo Liu, Shengcai Zheng, H. He
Oct 28, 2009
Citations
0
Influential Citations
63
Citations
Journal
Chemical communications
Abstract
Highly regio- and enantioselective allylic alkylation of fluorobis(phenylsulfonyl)methane (FBSM) has been realized by [Ir(COD)Cl](2)/phosphoramidite, affording enantiopure fluorobis(phenylsulfonyl)methylated compounds bearing a terminal alkene, which could be converted to monofluoro-methylated ibuprofen in just two steps without loss of the optical purity (95% ee).