Wen-Xue Huang, Chang-Bin Yu, Lei Shi
Jun 9, 2014
Citations
0
Influential Citations
35
Citations
Journal
Organic letters
Abstract
Highly enantioselective iridium-catalyzed hydrogenation of pyrrolo[1,2-a]pyrazinium salts has been achieved, providing a direct access to chiral 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine derivatives with up to 95% ee. The key feature of the reaction is the addition of cesium carbonate, which increases the conversion and prohibits the racemization pathway of products.