K. Burger, I. Zay, G. Takácsi Nagy
1985
Citations
0
Influential Citations
11
Citations
Journal
Acta pharmaceutica Hungarica
Abstract
A novel, water soluble, electrically neutral polynuclear iron(III) mixed ligand complex has been prepared for use in parenteral iron therapy. The composition of the new compound has been determined by preparative and analytical methods. Osmomotic pressure measurements have shown its polymeric nature. The complex molecule has a composition of Fe8L2D2AcO(OH)19 where L denotes the lactiobionate ion, D stands for one glucopyranose unit of dextrane and Ac is the acetate ion. Iron(III) acetate is the starting material in the preparation of the complex. The acetate neutralises the protons liberated in the interaction of iron(III) and the ligands and the acetic acid formed in this reaction is removed by steam distillation. An aqueous solution of 1.8 mol dm−3 iron concentration was prepared which has an osmotic pressure below 300 mosmol.