M. Palusiak, A. Pfitzner, M. Zabel
Apr 15, 2004
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Journal
Acta crystallographica. Section C, Crystal structure communications
Abstract
In methyl [5-methoxy-4-(4-methoxyphenyl)isochroman-3-yl]acetate, C(20)H(22)O(5), (I), and methyl [4-(2,5-dimethoxyphenyl)-8-methoxyisochroman-3-yl]acetate, C(21)H(24)O(6), (II), the heterocyclic rings adopt half-chair conformations. The substituents at the 3- and 4-positions are in a trans configuration in both (I) and (II), being in an axial conformation in (I) and in an equatorial conformation in (II). The crystal structure of (I) is stabilized by weak C-H.O hydrogen bonding, leading to the formation of an infinite three-dimensional network. Compound (II) crystallizes in a chiral space group. This feature, which was also found in previously investigated isochroman derivatives, is related to the arrangement of substituents attached to the isochroman moiety.