V. Gangan
Aug 31, 2022
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Journal
International Journal for Research in Applied Science and Engineering Technology
Abstract
Abstract: Isoeugenol has wide medical applications. It is used in manufacturing perfumeries, flavorings, essential oils (odour description: Clove, spicy, sweet, woody) and in medicine (local antiseptic and analgesic). Its analogues also show various biological activities which prompted us to synthesize few more analogues for their future applications as bioactive molecules. These were synthesized by coupling isoeugenol with benzoyl chloride / substituted benzoyl chloride / acetyl chloride using pyridine as a base in dichloromethane as a solvent at 150C to RT for 8hrs. These synthesized analogues were unambiguously characterized by 1H NMR, elemental analysis and Mass spectral data. Few of them showing promising antibacterial activity.