Rama Mohana Reddy Jaggavarapu, Venkatanarayana Muvvala, Venkata Reddy.G
Dec 9, 2020
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Current organic synthesis
Abstract
INTRODUCTION The origin, isolation, and characterization of (Z)-isopropyl 7-((1R, 2R, 3R, 5S)-2-((1E, 3Z)-3-fluoro4-phenoxybuta-1, 3-dienyl)-3, 5-dihydroxycyclopentyl) hept-5-enoate, an impurity found in the preparation of an antiglaucoma agent-Tafluprost has been described. MATERIALS AND METHODS Further, an enantiospecific synthesis of (Z)-isopropyl 7-((1R, 2R, 3R, 5S)-2-((1E, 3Z)-3-fluoro-4- phenoxybuta-1, 3-dienyl)-3, 5-dihydroxycyclopentyl) hept-5-enoate has been revealed using deoxofluorination as a key transformation of the strategy. RESULTS AND DISCUSSIONS Moreover, the impurity showing anti-glaucoma properties in docking studies with respect to bimatoprost. CONCLUSION The extent of our work towards docking studies, the present impurity molecule showing almost the same biological activity with respect to Tafluprost.