L. Baolin
2008
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Journal
Journal of Ankang University
Abstract
Osthol(C15H16O3) was the first isolated from the fruits of Libanotis buchtormensis(Fisch) DC growing wildly in the Taibai Mountain,the configuration and stereochemistry structure of osthol were analyzed by NMR spectra and single-crystal X-ray diffraction.Methods:The fruits of L.buchtormensis was extracted by 95% ethanol and separated by using silica gel column chromatography;colorless crystals of osthol were obtained from a solution of 95% ethanol by slow evaporation at room temperature.The molecule and crystal structure were analyzed by NMR spectra and X-ray crystal diffraction.Results:In the molecule of osthol,the coumarin nuclear is in a plane while the 3-methylbut-2-enyl group is in other plane,and the dihedral angel of two planes is 74.45°.The crystal of osthol is in triclinic crystal system with space group:P-1,accurate lattice constants:a=7.5025(17),b=9.651(2),c=10.736(2),α=64.393(4)°,β=75.716(4)°,γ=71.679(4)°,and Z=2.Conclusion:The molecular configuration and crystal structure of osthol were determinated.