S. Drewes, H. Robinson, J. Gliemann
Jul 1, 1979
Citations
0
Influential Citations
3
Citations
Journal
Hoppe-Seyler's Zeitschrift fur physiologische Chemie
Abstract
Reaction of insulin with 2-chloro- or 2-iodo-N-methylpyridinium iodide affords, amongst others, an insulin analogue modified at tha A14-tyrosine residue. Degradative procedures which pinpoint the exact position of modification are described. Highest yields of the derivative are obtained using the 2-iodo-N-methylpyridinium iodide as reagent. In the mouse convulsion assay this derivative retains 72% of its activity.