A. G. Davidson, S. Chee, F. M. Millar
Aug 31, 1990
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Influential Citations
2
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Journal
International Journal of Pharmaceutics
Abstract
Abstract Spectral evidence is presented for the formation of an intermediate product during alkali hydrolysis of nitrazepam. The compound is obtained in maximum yield by heating a solution of nitrazepam in 0.1 M sodium hydroxide at 75°C for 15 min. A fast extraction technique has been developed that allows the isolation of the compound by solvent extraction with negligible hydrolysis to 2-amino-5-nitrobenzophenone. Structural elucidation by mass spectrometry, infrared spectrometry, proton magnetic resonance spectrometry, ultraviolet-visible spectrophotometry and elemental analysis has shown that the compound is N -( α -(2-amino-5-nitrophenyl)benzylidene glycine formed by cleavage of the 1,2 bond of nitrazepam.