Y. Sun, Wei Li, Seo-Young Yang
Mar 1, 2016
Citations
0
Influential Citations
23
Citations
Quality indicators
Journal
Journal of Functional Foods
Abstract
Abstract Aloe has long been used in food products, beverages and cosmetics, and as a traditional medicine to treat various diseases in many countries. In the present study, a new chromone, aloe resin E ( 1 ), and a new pyrone, aloenin C ( 11 ), together with thirteen known compounds were isolated from aqueous dissolved Aloe exudates and their structures were identified by spectroscopic analysis. Nuclear factor kappa B (NF-κB) inhibitory activity of the isolated compounds was evaluated using an NF-κB luciferase assay in HepG2 cells. Among them, 7-hydroxy-5-(hydroxymethyl)-2-methylchromone ( 4 ), 5-(( S )-2′-oxo-4′-hydroxypentyl)-2-hydroxymethylchromone ( 9 ), and aloenin aglycone ( 13 ) showed significant inhibitory effects against TNFα-induced NF-κB transcriptional activity in a dose-dependent manner with IC 50 values ranging from 14.92 to 18.70 µM. Furthermore, the transcriptional inhibition of compounds 4 , 9 , and 13 was confirmed by a decrease in the expression of inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule-1 (ICAM-1) genes in HepG2 cells.