Xu Ya
2015
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Journal
Chemical Journal of Chinese Universities-chinese
Abstract
In order to investigate new bioactive compounds,a piece of fungi Aspergillus aculeatus was obtained from the Jinyun mountain soil in Chongqing,China.By fermentation using Potato Dextrose(PD) within 14 d at 28 ℃,the extraction of ethyl acetate(103 g) was obtained.The extraction was then used for isolation of compounds through a series of study by classical separation methods,for example Octadecyl Silane(ODS) and Sephadex LH-20.Two new compounds 2-(2',4',6'-trihydroxy phenyl) benzene-(7-hydroxy-5-methyl)chromone(1) and(E)-4-hydroxy-3-[(4-hydroxy-3-methylbut-2-en-1-yl) oxy] benzoic acid(2) were obtained.The structures were elucidated using mass spectrometry(MS),one demensional nuclear magnetic resonance spectroscopy(1D NMR),heteronuclear multiple bond correlation(HMQC),heteronuclear single quanturn correlation(HMBC) and rotating-frame overhauser effect spectroscopy(ROESY).Other two known compounds 2-(2'-hydroxypropyl)-5-methyl-7-hydroxychromone(3) and(3R,4S)-8-hydroxy-3,4,5-trimethyl-6-oxo-4,6-dihydro-3H-isochromene-7-carboxylic acid(4) were obtained.Compounds 2 to 4 exhibited some 2,2-diphenyl-1-picrylhydrazyl(DPPH) antioxidant activity.