M. Mesaik, Azizuddin, S. Murad
Nov 1, 2009
Citations
2
Influential Citations
47
Citations
Quality indicators
Journal
Phytotherapy Research
Abstract
Casticin (1), a flavonoid isolated from the aerial parts of Vitex agnus‐castus, was found to be a potent immunomodulatory and cytotoxic compound. The activity was tested in vitro for chemiluminescence, chemotaxis, T‐cell proliferation and cytotoxicity. Casticin (1) exhibited a significant inhibitory effect on monocyte oxidative burst in a dose dependent manner. It was found to have a significant suppressive effect on the chemotaxic action at higher concentrations on fMLP (10−8 m) stimulated neutrophils. It also showed a potent suppressive effect on PHA stimulated T‐cell (PMBC). Copyright © 2009 John Wiley & Sons, Ltd.