F. Gross, Elizabeth A. Lewis, M. Piraee
Feb 11, 2002
Citations
1
Influential Citations
17
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
3' -O-acetylchloramphenicol, commonly formed from chloramphenicol by resistant bacteria, has been isolated from the antibiotic-producing organism. Biosynthetic experiments suggest that it is a protected intermediate in chloramphenicol biosynthesis, implicating acetylation as a self-resistance mechanism in the producing organism.