Wei-Yi Ding, Yong-Ming Yan, Xiao-Hui Meng
Jun 11, 2020
Citations
1
Influential Citations
20
Citations
Quality indicators
Journal
Organic letters
Abstract
Aspongdopamines A and B (1 and 2), unusual adducts composed of N-acetyldopamine and adenine were isolated from the insect Aspongopus chinensis. Compounds 1 and 2 are positional isomers both isolated as racemates. Chiral separation assisted by 14-step total synthesis and computation including vibrational circular dichroism calculations allowed us to unambiguously assign the absolute configurations of eight stereoisomers. Renal fibrosis inhibition of the stereoisomers was evaluated in TGF-β1-induced rat kidney epithelial cells.