A. Chilin, P. Rodighiero, A. Guiotto
Mar 1, 1998
Citations
0
Influential Citations
13
Citations
Journal
Synthesis
Abstract
: 4-Amino-2-methylbenzofurans are quantitatively converted to 4-hydroxy-2-methylindoles in acidic medium. The rear-rangement mechanism involves the ring opening of the furan ring to produce an intermediate carbocation, which undergoes ring closure to the indole system. Isomerization takes place only in the presence of a methyl substituent in 2 position.