Oliver Kreye, B. Westermann, L. Wessjohann
Nov 21, 2007
Citations
0
Influential Citations
12
Citations
Journal
Synlett
Abstract
The application of 2-(2,2-dimethoxyethyl) phenyl iso-nitrile in Ugi, Passerini, and Ugi-Smiles reactions is described. The simple transformation to highly activated indolyl amides allows functional-group conversion of the isonitrile moiety into a variety of carboxylic acid derivatives, overall acting as a neutral, nucleophilic COOH equivalent.