M. Okamoto, M. Tabe, T. Fujii
Mar 1, 1995
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0
Influential Citations
28
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract The chiral β-amino alcohols-catalyzed addition of diisopropylzinc to steroidal 24-aldehydes successfully provided 24( R )-hydroxycholesterols in good yields with high diastereoselectivities, which are synthetic intermediates of 1 α ,24( R )-dihydroxyvitamin D 3 ( 1 ). α,β-Unsaturated steroidal aldehydes were found to give the corresponding isopropylated adducts in much higher yields (up to 91%) than those of saturated steroidal aldehydes.