H. Hidaka, Y. Suzuki, M. Shibuya
2005
Citations
0
Influential Citations
4
Citations
Journal
Handbook of experimental pharmacology
Abstract
The light of molecular pharmacology research has been focused on protein kinase inhibitor sulfonamide derivatives since 1978. Our studies on naphthalene and isoquinoline sulfonamide derivatives over the last 25 years have achieved a pronounced contribution toward elucidating the physiological function of various protein kinases and, moreover, toward developing a new type of medicine. This chapter relates to the discovery of new protein kinase inhibitors, their mechanisms of action, and their clinical application in Japan.