Shi Jing-shan
2007
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
The Chinese Pharmaceutical Journal
Abstract
OBJECTIVE To investigate the effect of isorhynchophylline(Isorhy) on platelet aggregation or thrombosis,and explore preliminarily to its mechanism.METHODS Rat platelet aggregation was determined;TXB2 or 6-keto-PGF1α contents were assessed by Born method and radioimmunoassay respectively.The death rate within 15 min was determined with collagen plus adrenaline induced thrombus model in mice.RESULTS iv Isorhy(2.5,5,10 mg·kg-1) was shown to inhibit markedly the rats platelet aggregation induced by ADP,collagen,arachidonic acid(AA) or thrombin in a dose-dependent manner;iv Isorhy 50 and 100 mg·kg-1 significantly reduced the death rate of mice.Isorhy(0.65,1.30 mmol·L-1) visibly decreased TXB2 generation induced by collagen in rabbit's platelet rich plasma.However,Isorhy had no significant influence on 6-keto-PGF1α generation in rabbit plasma.CONCLUSION Isorhy may significantly inhibit the platelet aggregation and thrombosis,whose mechanism that depresses the platelet aggregation induced by collagen may,at least partly,be due to the decrease of TXA2 level.