F. Clerici, M. Gelmi, R. Soave
Jun 17, 2002
Citations
0
Influential Citations
13
Citations
Journal
Tetrahedron
Abstract
Abstract The reaction of NaN3 with 5-substituted 3-diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxides is presented affording [2-cyano-1-diethylamino-2-(4-methoxyphenyl)-ethylidene]-sulfamic acid derivatives, 3-diethylamino-1,1-dioxo-4-(4-methoxyphenyl)-1,2-dihydro-[1,2]thiazete-4-carbonitrile, 3-diethylamino-7-methoxy-1,1-dioxo-1,4-dihydro-benzo[e][1,2]thiazine-4-carbonitrile or triazole derivatives. The outcome of the reaction strongly depends on the C-5 substituent and the correct choice of the reaction conditions allows direction of the reaction towards the formation of the sulfamic esters or the [1,2]thiazete carbonitrile or the triazoles in satisfactory yield.