Zi‐Jing Zhang, Jin Song
Aug 21, 2018
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Influential Citations
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Journal
Organic chemistry frontiers
Abstract
An efficient isothiourea-catalyzed stereoselective formal [4 + 2] cycloaddition of α-chloro cyclic hydrazones with carboxylic acids has been developed. Under mild conditions, a series of functionalized 4,4a,5,6-tetrahydrobenzo[h]cinnolin-3(2H)-one derivatives with two consecutive stereocenters were obtained in high yields with excellent diastereo- and enantioselectivities (up to >99% ee).