Sanjeev Jain, V. Sehgal
Jan 1, 2001
Citations
1
Influential Citations
51
Citations
Journal
International Journal of Dermatology
Abstract
Itraconazole is a triazole with three nitrogen atoms in the ®ve-membered azole ring. It was synthesized in 1980 and was examined in clinical trials in the early 1980s. Itraconazole(R-51211), (6)-cis-4-[4-[4-[4-[2-(2,4-dichlorophenyl)-2, (1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4yl] methoxyphenyl] -1-piperazinyl) phenyl] -2,4-dihydroxy2-(1-methylpropyl)-3H-1,2,4-triazol]-3-one, has a molecular weight of 705.65. It is a weak base, and is practically micronized at physiologic pH.