J. Beattie, G. Breault, Rebecca Ellston
Sep 15, 2003
Citations
0
Influential Citations
72
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
Using a high-throughput screening campaign, we identified the 4,6-bis anilino pyrimidines as inhibitors of the cyclin-dependent kinase, CDK4. Herein we describe the further chemical modification and use of X-ray crystallography to develop potent and selective in vitro inhibitors of CDK4.