Csaba Paizs, M. Toșa, Viktória Bódai
Jul 4, 2003
Citations
0
Influential Citations
27
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract Kinetic resolution of racemic 1-(benzofuran-2-yl)ethanols rac - 1a – d was performed by lipase-catalyzed enantiomer selective acylation ( E ≫100) yielding (1 R )-1-acetoxy-1-(benzofuran-2-yl)ethanes ( R )- 2a – d and (1 S )-1-(benzofuran-2-yl)ethanols ( S )- 1a – d in highly enantiopure form. The degree of enantiomer selectivity for enzymatic alcoholysis/hydrolysis processes starting from racemic 1-acetoxy-1-(benzofuran-2-yl)ethane rac - 2 was also tested under various conditions including supercritical CO 2 medium. Racemization-free lipase-catalyzed ethanolysis of the (1 R )-1-acetoxy-1-(benzofuran-2-yl)ethanes ( R )- 2a – d yielded almost quantitatively the enantiopure (1 R )-1-(benzofuran-2-yl)ethanols ( R )- 1a – d .