E. H. Jensen, D. J. Lamb
Apr 1, 1964
Citations
0
Influential Citations
19
Citations
Journal
Journal of pharmaceutical sciences
Abstract
The shelf-life of a potential formulation of fluprednisolone acetate was predicted from kinetic measurements. Subsequent assay of samples stored at ambient temperatures confirmed the predicted stability. The degradation of the steroid ester to products devoid of the 17-dihydroxyacetone moiety followed a two-step sequence: ester → alcohol → degradation products. The kinetics of this pathway were interpreted on the basis of consecutive first-order reactions. Quantitative thin-layer chromatography was used to determine the two major components in solution.