E. Nelson
May 1, 1962
Citations
0
Influential Citations
9
Citations
Journal
Journal of Theoretical Biology
Abstract
Abstract The relationship between excretion rate of free and acetylated sulfonamides during therapy with this class of drugs was examined with respect to the usual dosage regimen employed, the kinetics of their absorption and metabolism, and with respect to the volumes of urine needed to be secreted to prevent crystalluria. The equations developed allow the calculation of the excretion rate of unchanged and acetylated sulfonamides at times of dosage and in the interval between doses. Using sulfathiazole, as an example, it was found that excretion rate of acetylsulfathiazole after administration of a sufficient number of doses to yield constant values for excretion rate of this material at times of dosage, was relatively independent of drug absorption rate. Similarly, excretion rate between doses was relatively independent of drug absorption rate and did not deviate too markedly from the rate at times of dosage. On the basis of these calculations, high rates of urine flow need to be maintained in order to prevent crystalluria. Calculations on excretion rate of unchanged sulfathiazole indicated that crystalluria due to this material is possible.