B. Stanisz
May 1, 2005
Citations
0
Influential Citations
13
Citations
Journal
Reaction Kinetics and Catalysis Letters
Abstract
SummaryThe kinetics of degradation of lisinopril (LIS) in solid phase in presence of humidity at 343, 353, 358 and 363 K has been investigated. Changes of the LIS concentration were followed by an HPLC method with UV detection. The thermodynamic parameters at 293 K of degradation of LIS in solid phase Ea (kJ/mol) = 166 ± 47; ΔH*(kJ/mol) = 163 ± 48; ΔS*(J/(K × mol)) = 99 ± 135 for RH = 76.4% have been calculated. Identification of the product of LIS degradation in solid phase was carried out by HPLC-MS. Diketopiperazine derivative of LIS was the major product of its decomposition in the presence of humidity.