W. Heinzel, T. Kronbach, W. Voelter
Dec 1, 1982
Citations
0
Influential Citations
2
Citations
Journal
Zeitschrift für Naturforschung B
Abstract
A synthesis of high yields of TP 5 is described. The a-amino functions were blocked by the acid-labile 1-(1 -adamantyl)-1-methylethoxycarbonyl-(Adpoc)group. The Adpoc group is cleaved under mild acidolytic conditions with 3% TFA in CH2CI2 while the tert-butyl residues remained intact. This selective cleavage of the Adpoc group compared with the Boc and tert-butyl residues allows new strategies for the synthesis of large peptides