S. Ryabukhin, A. S. Plaskon, D. Volochnyuk
Sep 28, 2007
Citations
1
Influential Citations
66
Citations
Journal
Journal of combinatorial chemistry
Abstract
Chlorotrimethylsilane (TMSCl) has been utilized as an efficient promoter and water scavenger in the Knoevenagel condensations of aromatic aldehydes with various methylene active compounds. High yields and a simple workup of target compounds enables the facile generation of combinatorial libraries comprising 11,000 compounds of high structural and functional diversity.