Yan Zhang, Yun‐Zhen Jiang, Xiao‐Tian Liang
Aug 27, 2010
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Journal
Chinese Journal of Chemistry
Abstract
The reaction between ethyl 3-bromopyruvate and p-substituted anilines was found to involve the unexpected participation of acetone (solvent) forming N-aryl-5-methyl-pyrrole-3-carboxylates. The influence of p-substituents of aniline and the feasibility with other ketones were studied. N-aryl-indole-3-carboxylate (17) was synthesized successfully with this method. The unique character of p-methoxy-aniline in this reaction was discussed.