J. Sufrin, J. Lombardini, D. Keith
May 31, 1982
Citations
0
Influential Citations
33
Citations
Quality indicators
Journal
Biochemical and biophysical research communications
Abstract
Abstract L -2- Amino -4- methoxy - cis - but -3- enoic acid was synthesized and found to be an extremely potent inhibitor of ATP: L-methionine adenosyltransferase isozymes of rat liver and Novikoff solid hepatoma. The inhibitory potency of L -2- amino -4- methoxy - cis - but -3- enoic acid was found to be significantly higher than that of its structural analogues, L-methoxinine and L -2- amino -4- methoxy - trans - but -3- enoic acid . The Ki values of L -2- amino -4- methoxy - cis - but -3- enoic acid and the Km values of L-methionine are comparable for the rat liver and tumor isozymes, suggesting a close correlation between the enzyme-bound conformations of these two molecules.