James B. Springer, O. Colvin, S. Ludeman
Feb 1, 2007
Citations
0
Influential Citations
5
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
A variety of deuterated 3-amino-1-propanols were made by the LiAlD 4 or AlD 3 reduction of nitrile or ester precursors. The labeled aminopropanols and/or deuterated bis(2-chloroethyl)amines were used to synthesize [4,4- 2 H 2 ]-, [6,6- 2 H 2 ]-, [α,α.α',α- 2 H 4 ]-, and [4,4,β,β,β',β'- 2 H 6 ]-cyclophosphamide. The labeled aminopropanols were also used to synthesize deuterated 3-(2'-benzyloxyethylamino)-1-propanols [BnOCH 2 CH 2 NH(CH 2 ) 3 OH] which, along with labeled and unlabeled 2-chloroethylamines, led to [4,4- 2 H 2 ]-, [6,6- 2 H 2 ]-, [α,α- 2 H 2 ]-, [α',α'- 2 H 2 ]-, [α,α.α',α'- 2 H 4 ]-, and [6,6,α,α,α',α'- 2 H 6] -ifosfamide.