Sandra Ferrer, D. Naughton, M. Threadgill
May 1, 2002
Citations
0
Influential Citations
4
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
Treatment of 2-chloro-4,6-(dimethylamino)-1,3,5-triazine with trideuteromethylamine gave 4,6-(dimethylamino)-2-trideuteromethyl-1,3,5-triazine, an isotopomer of the experimental anticancer agent pentamethylmelamine (PMM). Mitsunobu coupling with 1,2-dimethyl-3-hydroxymethyl-5-methoxy-indole-4,7-dione gave 1,2-dimethyl-3-(N-(4,6-bis(dimethylamino)-1,3,5-triazin-2-yl)-N-trideuteromethylaminomethyl)-5-methoxyindole-4,7-dione. This conjugate is a potential reductively triggered prodrug of PMM. Copyright © 2002 John Wiley & Sons, Ltd.