A. Grinev, É. S. Krichevskii, O. Romanova
Oct 1, 1983
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Journal
Chemistry of Heterocyclic Compounds
Abstract
Abstract5,6-Dihydro-8-methyl-4H-pyrazino[3,2,1-j,k]carbazole was obtained by the reaction of α-bromoacetaldehyde dibutylacetal, ammonium acetate, and 1,2,3,4-tetrahydro-6-methyl-1-ketocarbazole in acetic acid. The reduction of 5,6-dihydro-8-methyl-4H-pyrazino[3,2,1-j,k]carbazole or its hydrochloride with sodium borohydride leads to 2,3,3a,4,5,6-hexahydro-8-methyl-1H-pyrazino[3,2,1-j,k]carbazole hydrochloride — the medicinal preparation pirazidol.