A. R. Timms, L. A. Kelly, R. Ho
Aug 1, 1969
Citations
0
Influential Citations
26
Citations
Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract The hypolipidemic properties of 1-methyl-4-piperidyl bis ( p -chlorophenoxy) acetate (SaH 42-348) in the male Wistar rat have been described. This agent is eight to nine times more active on a weight for weight basis than chlorphenoxy isobutyric acid ethyl ester (CPIB) (Atromid-S), and in common with CPIB lowers the levels of all major classes of serum lipid. No increase in liver lipid content was seen in animals treated with SaH 42-348, although hepatomegaly was seen after treatment with SaH 42-348 or with CPIB. Evidence is presented suggesting that the mechanism of action of SaH 42-348 in lowering serum cholesterol in the rat differs from that of CPIB. Thus, it was not possible to demonstrate that SaH 42-348 inhibited cholesterol biosynthesis in vivo from 1- 14 C acetate, while the inhibitory effect of CPIB was readily demonstrated. In addition, n - propylthiouracil (PTU) inhibited the hypocholesterolemic activity of CPIB in both normolipemic and hyperlipemic rats, whereas the activity of SaH 42-348 was unaffected by PTU.