Hervé Lefebvre, V. Contesse, C. Delarue
1996
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
European Journal of Clinical Pharmacology
Abstract
Objective: In the present study, we investigated the effect of zacopride on corticotropin (ACTH) and cortisol secretion in healthy volunteers. Male subjects received a single oral dose of placebo, 10 μg zacopride or 400 μg zacopride. Plasma ACTH, cortisol and aldosterone concentrations were measured before and during the 3 h following the administration of the drug. Results:For none of the doses did zacopride cause any modification of plasma ACTH or cortisol levels. In contrast, administration of 400 μg zacopride induced a significant increase in plasma aldosterone levels.Conclusion:Our results indicate that in humans serotonin-evoked stimulation of ACTH secretion is not mediated through serotonin4 (5-HT4) receptors. Together with previous findings, these data indicate that the stimulatory effect of 5-HT4 receptor agonists on aldosterone secretion in man can be ascribed solely to a direct action on glomerulosa cells.