F. Csende
Apr 12, 2006
Citations
0
Influential Citations
2
Citations
Journal
Arkivoc
Abstract
Reaction of 3-(p-toluoyl)propanoic acid, 1a (R = H) with refluxing acetic anhydride resulted quantitatively in 2, a β,γ-unsaturated γ-lactone, which was then converted into 3a, an α,βunsaturated lactone by isomerization with triethylamine. The methyl- substituted compound 1b (R = Me), an analogue of 1a, afforded the 2(5H)-furanone 3b directly by heating with Ac2O. Similar reaction of the cycloalkane- containing oxocarboxylic acids (4,5) led in excellent yields to the fused furanones 6 and 7, while treatment of 2-formyl-, 2-acetyl- and 2-(p-toluoyl)benzoic acids (8a-c) with Ac2O gave the 3-acetoxy-1-(3H)-isobenzofuranones, 9a-c.